I have pretty much the same problem with multiple NVIDIA drivers on PC with nVidia GTX 1050 card, old Gigabyte EP43-DS3 motherboard and Intel Core2 Q9550, multiple Ubuntu versions and kernels
Entry in my syslog appear like the following around the time I have a full lockup
Apr 18 23:57:31 hobbs /usr/libexec/gdm-x-session[2294]: (WW) NVIDIA(0): WAIT (1-S, 17, 0x093b, 0x000034d8, 0x00007f28)
Apr 18 23:57:34 hobbs /usr/libexec/gdm-x-session[2294]: (WW) NVIDIA(0): WAIT (2-S, 17, 0x0943, 0x000034d8, 0x00007f64)
Keyboard and mouse lockup (including caps/num lock)
I’ve gone back to the 470 driver as I think it happens less frequently with it. I’ve seen posts saying that this doesn’t happen with the 460 driver
I don’t have reproduction steps but Firefox can often trigger the problem. At times Firefox will also trigger an almost lock up (GUI is locked up) but keyboard can still respond and if I go to a terminal, eg and do a killall firefox I can sometimes get the GUI to respond again but sometimes it’s a full reboot required.