Shader debug information takes up a lot of space and isn’t necessary for executing shaders. The Direct3D shader compiler allows you to strip debug data out of compiled shaders and place the debug data in a convenient location. Does Nsight have a mechanism to set the file (ie. D3D_BLOB_DEBUG_NAME) and can a search path for the PBD be specified?
Bad News: Not Currently.
Good News: We expect to have support for this in our next release!