How to disable UART?

I use the FIND command to find the p3448-0000.conf file.
Find its position at :/run/user/1000/gvfs
I tried to use vim to write this conf file but it show Permission denied,so i used ls -al commnd and it show

root@jebot-desktop:/run/user/1000# ls -al
ls: cannot access 'gvfs': Permission denied
total 0
drwx------ 10 root jebot 240 Sep  1 20:40 .
drwxr-xr-x  3 root root   60 Sep  1 20:13 ..
srw-rw-rw-  1 root jebot   0 Sep  1 20:13 bus
drwx------  3 root jebot  60 Sep  1 20:13 dbus-1
drwx------  2 root jebot  60 Sep  1 20:13 dconf
drwx--x--x  2 root jebot  60 Sep  1 20:13 gdm
drwx------  2 root jebot 140 Sep  1 20:13 gnupg
d?????????  ? ?    ?       ?            ? gvfs
drwx------  2 root jebot 100 Sep  1 20:13 keyring
drwx------  2 root jebot  80 Sep  1 20:13 pulse
drwxr-xr-x  3 root jebot 100 Sep  1 20:13 systemd
-rw-------  1 root jebot   0 Sep  1 20:40 update-notifier.pid

How can I solve this problem to successfully disable UART?

I do not know the correct way to disable serial console on a Nano, but anything in a gvfs filesystem is intentionally not accessible by most processes…this is not an error, it is just how that filesystem is used and intended to work. Such files are not actual real files and exist in RAM…therefore if you could edit such a file, then the result would disappear upon reboot. Serial console disable is usually a combination of device tree and extlinux.conf edits, but I don’t know the details for Nano.