In theory you could use RS485, but I only know about the RS232 in terms of actual use and setup (RS485 probably has some hurdles to get past, whereas if the speed is not too high RS232 would “just work”). Serial could certainly work, especially serial over USB (although USB has its own issues if you want low latency real time). Do you have any example A/D converters you’ve been considering, along with a URL with the specs? It might be possible to get an idea by looking at those and perhaps expanding on the topic. Especially useful would be to know how many A/D converters, what resolution, and what kind of bandwidth or update rate you are looking at. If you have a unit you are currently using with an RPi, then it might be useful to see the specs on that.
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