lossless encoding of a .yuv file (subsampling 4:2:0)

Is it possible to encode a .yuv file subsamplied 4:2:0 with a lossless preset?
By using NvEncoderPerf and the command
NvEncoderPerf -i input_file_420.yuv -yuv444 0 -fps 30 -size 2560 1600 -preset lossless -o ouptut_file.h264
the encoding is done but when display the video with VLC, it’s very bad.

Does it make sense to encode lossless with a 4:2:0 subsampling?