The forever bug with nvidia-settings thats in all releases and affects all hardware is still present.
Please nvidia, fix this!
.nvidia-settings-rc or config file is not read or applied on loading nvidia-settings util, this causes a reset of certain settings on exiting nvidia-settings to the config file.
In my case the Gamma settings are constantly reset to 1.0 upon using the nvidia-settings util.
A monkey can reproduce this bug btw, just load nvidia-settings, set a custom gamma change to a display, save to config file. Exit, reload nvidia-settings then quit, notice it resets and also edits the config file back to defaults (1.00000000).