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To ensure better visibility and support, I’ve moved your post to the Jetson category where it’s more appropriate
Are you using the devkit or custom board for Orin NX?
What’s the Jetpack version in use?
As my understanding, the configuration in L4TConfiguration.dtbo will be loaded only for the first boot after flash.
May I know what’s your use case and the requirement?
Do you want to update some efi variables in runtime?
It seems you have to reflash the board since the partition for efi variable would not be updated after capsule update or OTA update.
If you have multiple devices, I would suggest using massflash package to apply the change.