Maybe you really should try this workaround with newer drivers.
As the person here mentioned, this did fix his Doom Eternal issue on his desktop system too.
Which my original report about Doom 2016 was also pointing out a regression happened after 440 drivers, which you are currently relying on and call it better than others.
What does it do? Indication is, this GLX vendor library name var causes app profiles to not apply. From Doom 2016 to Doom Eternal and most likely any other apps that has workarounds in NV driver.
On a single NV gpu system reported vendor is NV without needing to use mentioned var (only useful if you need finer selection of GPU’s comes to GL stuff, that is the aim of it)
As you can see from previous NV driver changelogs, driver has a profile for DXVK too in place.
So it might worthy to give a shot.