Hi 837535053,
Are you using the devkit or custom board for AGX Orin?
Is MSI *******
your custom network device since I cannot find it on AGX Orin devkit?
Please refer to IRQ Balancing - #6 by sumitg to configure the other cores to handle the interrupt.
$ sudo su
# cd /proc/irq/331
# cat smp_affinity
# cat smp_affinity_list
# echo ff > smp_affinity
Please also refer to R36.3 Patch to re-enable GICv2m for PCIe MSI interrupts and restore I/O performance - Jetson & Embedded Systems / Jetson AGX Orin - NVIDIA Developer Forums and check if those patches can help in your case.