CUDA and 3 Monitors

Hello, I need to use 3 monitors and in order to do so I need two NVIDIA cards in SLI, could I use two GTX 580 in SLI by using CUDA for Premiere without having problems? I do know that Mercury requires only one GPU, but I need to find out if I can keep connected the two cards in SLI and use Premiere with MPE.
I am using a Matrox RT.X2, could this use any type of conflicts?

This is my (future) Workstation configuration:
-Mainboard: ASUS Rampage III Extreme
-Processor: i7 970
-RAM: 12Gb 1600
-Graphic: 2x GTX580 SLI (or ATI HD6970 with Eyefinity)
-Power: Enermax 1020
-Audio: Creative X-Fi Elite Pro
-Matrox RT.X2
-HDD: 3x 500Gb
Software: Win7 64bit - CS5 Premiere, After Effects

In conclusion:
I would like to know now if by disabling the SLI I can still have the possibility of using 3 monitors with two identical cards while I am working in PPRO using of course one GPU
I would like to use two IDENTICAL CARDS and put them i SLI whenever i need the Surround vision in videogames, if possible