Full symbolic debugging of OptiX programs in cuda-gdb isn’t supported yet, we are working on that. SASS level debugging works, but you have to figure out the correspondence to your source code manually. That can be pretty difficult, I don’t expect that to be a helpful suggestion or viable workaround unless you are extremely comfortable with assembly debugging. Breakpoints sometimes work, so you may be able to use them to help narrow down the region causing your misaligned address exception.
Here are a couple of threads with some suggestions for other possible ways to debug: