Microsoft Flight Simulator 2020 crashes about half way through the initial loading screen on Wayland. Does not affect X11.
This was introduced in driver version 555 and is reported here with more detail: Microsoft Flight Simulator crashes with "!status && "vkAcquireNextImageKHR"" while loading on Wayland since 555
(Edit: Does not matter whether I run the game in DX11/DXVK or DX12/VKD3D. Same experience.)