x86_64 is for a desktop PC. You have no possibility of running this on a Jetson. Maybe you could find an emulator, but this would be a really difficult and low performance route you would not find useful. You need the 64-bit ARM (ARMv8-a/arm64/aarch64) version of the PC program (same code compiled for the new architecture). Is there a 64-bit ARM release already? Is there source code available you could compile?
Serial ports tend to rely on a driver loading for the UART to be seen. What kind of UART is it, e.g., USB? Is it an FTDI chipset? Some other chipset? Are you speaking of the UARTs already present on the TX2?