Parabricks

Topic	Replies	Views	Activity
Welcome to the NVIDIA Parabricks Developer Forum Welcome to our Developer Forum! This Developer Forum is open to the entire Parabricks community and is a great place to ask questions, exchange knowledge, and connect with fellow Parabricks users. If you have purchased…	1	2209	May 25, 2024
Latest Parabricks Releases New features, performance improvements and bug fixes by release.	4	574	October 21, 2025
Fine-tuned DeepVariant model in Parabricks 4.7.1: converter, make_examples version, 6-channel tensorrt , training , deepvariant	2	26	October 8, 2026
Feature request: --static-quantized-quals for applybqsr fq2bam	1	35	October 7, 2026
Parabricks Deepvariant Germline --mode Hybrid deepvariant	1	44	September 16, 2026
CRAM 3.1 Support deepvariant	3	123	September 16, 2026
Feature request: expose DeepVariant's --par_regions_bed in pbrun deepvariant ai , deepvariant	1	24	September 16, 2026
Pbrun haplotypecaller running error	7	217	September 11, 2026
Deepvariant error: deep_common2/vcf.cpp:1801] Allele ->A,A not found in probability dictionary ai , deepvariant	3	112	August 21, 2026
Pbrun genotypegvcf 4.7.1-1 stalls in PBBgzfFile.cpp when reading a 1326-sample GATK CombineGVCFs file with records larger than 64 KiB ai	1	56	August 14, 2026
Student Request for Brev.dev Credits - Regis University (PCOS Detection Project)	1	107	July 13, 2026
Kmer size control in haplotypecaller cuda	1	81	July 2, 2026
Fq2bam postsort/BQSR hangs and crashes on large WGS tumor samples — reproducible across Parabricks 4.6 and 4.7, two different GPU setups fq2bam	3	142	July 1, 2026
Rna_fq2bam GPU-STAR: illegal memory access at ~1,000,000 collapsed junctions, independent of --max-collapsed-junctions ai , bug	0	81	July 1, 2026
Ready2Run Parabricks DeepVariant on HealthOmics: silent 0-byte VCF from TensorRT engine version mismatch ai , fq2bam , deepvariant	0	80	June 20, 2026
Parabricks fq2bam CRAM output fails samtools index with CRAM slice offset does not match landmark ai , fq2bam	2	100	June 3, 2026
Why Does NVIDIA Parabricks Become Slower as More Samples Are Processed?	3	168	May 14, 2026
Bcftoolsmpileup and bcftoolscall remove in Parabricks 4.x?	1	73	May 13, 2026
[Help] Parabricks genotypegvcf for Multi-sample Joint Genotyping — Do I need to pre-merge GVCFs?	1	146	May 13, 2026
Standalone BQSR crashing but full FQ2BAM succeeding fq2bam	1	85	May 1, 2026
Memory leak crashing run at MarkDuplicates/BQSR stage in Fq2Bam ai , fq2bam	17	394	April 26, 2026
Why pbrun genotypegvcf only recognizes the last input file when processing multiple GVCFs on a large genome？	0	106	April 25, 2026
Can Parabricks generate CSI index when running fq2bam? fq2bam	2	109	April 22, 2026
Deepvariant_germline --keep-duplicates fq2bam	2	108	April 13, 2026
Question about CPU thread scaling and control in Parabricks	2	109	March 31, 2026
Outputting both VCF and gVCF deepvariant	4	167	March 31, 2026
How to run STAR-WASP mode in pbrun rna_fq2bam?	2	107	March 25, 2026
Sorting clarification for markdup	5	269	March 18, 2026
GenotypeGVCF in Parabricks 4.3.2 not using GPUs and ending with error	4	133	March 17, 2026
Fq2bam stalls in single-end recovery mode fq2bam	3	164	March 9, 2026

Welcome to the NVIDIA Parabricks Developer Forum

Welcome to our Developer Forum! This Developer Forum is open to the entire Parabricks community and is a great place to ask questions, exchange knowledge, and connect with fellow Parabricks users. If you have purchased…

1

2209

May 25, 2024

Latest Parabricks Releases

New features, performance improvements and bug fixes by release.

4

574

October 21, 2025

Fine-tuned DeepVariant model in Parabricks 4.7.1: converter, make_examples version, 6-channel

tensorrt , training , deepvariant

2

26

October 8, 2026

Feature request: --static-quantized-quals for applybqsr

fq2bam

1

35

October 7, 2026

Parabricks Deepvariant Germline --mode Hybrid

deepvariant

1

44

September 16, 2026

CRAM 3.1 Support

deepvariant

3

123

September 16, 2026

Feature request: expose DeepVariant's --par_regions_bed in pbrun deepvariant

ai , deepvariant

1

24

September 16, 2026

Pbrun haplotypecaller running error

7

217

September 11, 2026

Deepvariant error: deep_common2/vcf.cpp:1801] Allele ->A,A not found in probability dictionary

ai , deepvariant

3

112

August 21, 2026

Pbrun genotypegvcf 4.7.1-1 stalls in PBBgzfFile.cpp when reading a 1326-sample GATK CombineGVCFs file with records larger than 64 KiB

ai

1

56

August 14, 2026

Student Request for Brev.dev Credits - Regis University (PCOS Detection Project)

1

107

July 13, 2026

Kmer size control in haplotypecaller

cuda

1

81

July 2, 2026

Fq2bam postsort/BQSR hangs and crashes on large WGS tumor samples — reproducible across Parabricks 4.6 and 4.7, two different GPU setups

fq2bam

3

142

July 1, 2026

Rna_fq2bam GPU-STAR: illegal memory access at ~1,000,000 collapsed junctions, independent of --max-collapsed-junctions

ai , bug

0

81

July 1, 2026

Ready2Run Parabricks DeepVariant on HealthOmics: silent 0-byte VCF from TensorRT engine version mismatch

ai , fq2bam , deepvariant

0

80

June 20, 2026

Parabricks fq2bam CRAM output fails samtools index with CRAM slice offset does not match landmark

ai , fq2bam

2

100

June 3, 2026

Why Does NVIDIA Parabricks Become Slower as More Samples Are Processed?

3

168

May 14, 2026

Bcftoolsmpileup and bcftoolscall remove in Parabricks 4.x?

1

73

May 13, 2026

[Help] Parabricks genotypegvcf for Multi-sample Joint Genotyping — Do I need to pre-merge GVCFs?

1

146

May 13, 2026

Standalone BQSR crashing but full FQ2BAM succeeding

fq2bam

1

85

May 1, 2026

Memory leak crashing run at MarkDuplicates/BQSR stage in Fq2Bam

ai , fq2bam

17

394

April 26, 2026

Why pbrun genotypegvcf only recognizes the last input file when processing multiple GVCFs on a large genome？

0

106

April 25, 2026

Can Parabricks generate CSI index when running fq2bam?

fq2bam

2

109

April 22, 2026

Deepvariant_germline --keep-duplicates

fq2bam

2

108

April 13, 2026

Question about CPU thread scaling and control in Parabricks

2

109

March 31, 2026

Outputting both VCF and gVCF

deepvariant

4

167

March 31, 2026

How to run STAR-WASP mode in pbrun rna_fq2bam?

2

107

March 25, 2026

Sorting clarification for markdup

5

269

March 18, 2026

GenotypeGVCF in Parabricks 4.3.2 not using GPUs and ending with error

4

133

March 17, 2026

Fq2bam stalls in single-end recovery mode

fq2bam

3

164

March 9, 2026

Healthcare & Life Sciences Parabricks