Parabricks

Topic	Replies	Views	Activity
Welcome to the NVIDIA Parabricks Developer Forum Welcome to our Developer Forum! This Developer Forum is open to the entire Parabricks community and is a great place to ask questions, exchange knowledge, and connect with fellow Parabricks users. If you have purchased…	1	2219	May 25, 2024
Latest Parabricks Releases New features, performance improvements and bug fixes by release.	4	598	October 21, 2025
Fine-tuned DeepVariant model in Parabricks 4.7.1: converter, make_examples version, 6-channel tensorrt , training , deepvariant	2	45	October 8, 2026
Feature request: --static-quantized-quals for applybqsr fq2bam	1	53	October 7, 2026
Parabricks Deepvariant Germline --mode Hybrid deepvariant	1	56	September 16, 2026
CRAM 3.1 Support deepvariant	3	149	September 16, 2026
Feature request: expose DeepVariant's --par_regions_bed in pbrun deepvariant ai , deepvariant	1	37	September 16, 2026
Pbrun haplotypecaller running error	7	235	September 11, 2026
Deepvariant error: deep_common2/vcf.cpp:1801] Allele ->A,A not found in probability dictionary ai , deepvariant	3	125	August 21, 2026
Pbrun genotypegvcf 4.7.1-1 stalls in PBBgzfFile.cpp when reading a 1326-sample GATK CombineGVCFs file with records larger than 64 KiB ai	1	68	August 14, 2026
Student Request for Brev.dev Credits - Regis University (PCOS Detection Project)	1	123	July 13, 2026
Kmer size control in haplotypecaller cuda	1	92	July 2, 2026
Fq2bam postsort/BQSR hangs and crashes on large WGS tumor samples — reproducible across Parabricks 4.6 and 4.7, two different GPU setups fq2bam	3	157	July 1, 2026
Rna_fq2bam GPU-STAR: illegal memory access at ~1,000,000 collapsed junctions, independent of --max-collapsed-junctions ai , bug	0	88	July 1, 2026
Ready2Run Parabricks DeepVariant on HealthOmics: silent 0-byte VCF from TensorRT engine version mismatch ai , fq2bam , deepvariant	0	89	June 20, 2026
Parabricks fq2bam CRAM output fails samtools index with CRAM slice offset does not match landmark ai , fq2bam	2	109	June 3, 2026
Why Does NVIDIA Parabricks Become Slower as More Samples Are Processed?	3	189	May 14, 2026
Bcftoolsmpileup and bcftoolscall remove in Parabricks 4.x?	1	81	May 13, 2026
[Help] Parabricks genotypegvcf for Multi-sample Joint Genotyping — Do I need to pre-merge GVCFs?	1	153	May 13, 2026
Standalone BQSR crashing but full FQ2BAM succeeding fq2bam	1	95	May 1, 2026
Memory leak crashing run at MarkDuplicates/BQSR stage in Fq2Bam ai , fq2bam	17	422	April 26, 2026
Why pbrun genotypegvcf only recognizes the last input file when processing multiple GVCFs on a large genome？	0	122	April 25, 2026
Can Parabricks generate CSI index when running fq2bam? fq2bam	2	122	April 22, 2026
Deepvariant_germline --keep-duplicates fq2bam	2	119	April 13, 2026
Question about CPU thread scaling and control in Parabricks	2	122	March 31, 2026
Outputting both VCF and gVCF deepvariant	4	174	March 31, 2026
How to run STAR-WASP mode in pbrun rna_fq2bam?	2	117	March 25, 2026
Sorting clarification for markdup	5	286	March 18, 2026
GenotypeGVCF in Parabricks 4.3.2 not using GPUs and ending with error	4	151	March 17, 2026
Fq2bam stalls in single-end recovery mode fq2bam	3	182	March 9, 2026

Welcome to the NVIDIA Parabricks Developer Forum

Welcome to our Developer Forum! This Developer Forum is open to the entire Parabricks community and is a great place to ask questions, exchange knowledge, and connect with fellow Parabricks users. If you have purchased…

1

2219

May 25, 2024

Latest Parabricks Releases

New features, performance improvements and bug fixes by release.

4

598

October 21, 2025

Fine-tuned DeepVariant model in Parabricks 4.7.1: converter, make_examples version, 6-channel

tensorrt , training , deepvariant

2

45

October 8, 2026

Feature request: --static-quantized-quals for applybqsr

fq2bam

1

53

October 7, 2026

Parabricks Deepvariant Germline --mode Hybrid

deepvariant

1

56

September 16, 2026

CRAM 3.1 Support

deepvariant

3

149

September 16, 2026

Feature request: expose DeepVariant's --par_regions_bed in pbrun deepvariant

ai , deepvariant

1

37

September 16, 2026

Pbrun haplotypecaller running error

7

235

September 11, 2026

Deepvariant error: deep_common2/vcf.cpp:1801] Allele ->A,A not found in probability dictionary

ai , deepvariant

3

125

August 21, 2026

Pbrun genotypegvcf 4.7.1-1 stalls in PBBgzfFile.cpp when reading a 1326-sample GATK CombineGVCFs file with records larger than 64 KiB

ai

1

68

August 14, 2026

Student Request for Brev.dev Credits - Regis University (PCOS Detection Project)

1

123

July 13, 2026

Kmer size control in haplotypecaller

cuda

1

92

July 2, 2026

Fq2bam postsort/BQSR hangs and crashes on large WGS tumor samples — reproducible across Parabricks 4.6 and 4.7, two different GPU setups

fq2bam

3

157

July 1, 2026

Rna_fq2bam GPU-STAR: illegal memory access at ~1,000,000 collapsed junctions, independent of --max-collapsed-junctions

ai , bug

0

88

July 1, 2026

Ready2Run Parabricks DeepVariant on HealthOmics: silent 0-byte VCF from TensorRT engine version mismatch

ai , fq2bam , deepvariant

0

89

June 20, 2026

Parabricks fq2bam CRAM output fails samtools index with CRAM slice offset does not match landmark

ai , fq2bam

2

109

June 3, 2026

Why Does NVIDIA Parabricks Become Slower as More Samples Are Processed?

3

189

May 14, 2026

Bcftoolsmpileup and bcftoolscall remove in Parabricks 4.x?

1

81

May 13, 2026

[Help] Parabricks genotypegvcf for Multi-sample Joint Genotyping — Do I need to pre-merge GVCFs?

1

153

May 13, 2026

Standalone BQSR crashing but full FQ2BAM succeeding

fq2bam

1

95

May 1, 2026

Memory leak crashing run at MarkDuplicates/BQSR stage in Fq2Bam

ai , fq2bam

17

422

April 26, 2026

Why pbrun genotypegvcf only recognizes the last input file when processing multiple GVCFs on a large genome？

0

122

April 25, 2026

Can Parabricks generate CSI index when running fq2bam?

fq2bam

2

122

April 22, 2026

Deepvariant_germline --keep-duplicates

fq2bam

2

119

April 13, 2026

Question about CPU thread scaling and control in Parabricks

2

122

March 31, 2026

Outputting both VCF and gVCF

deepvariant

4

174

March 31, 2026

How to run STAR-WASP mode in pbrun rna_fq2bam?

2

117

March 25, 2026

Sorting clarification for markdup

5

286

March 18, 2026

GenotypeGVCF in Parabricks 4.3.2 not using GPUs and ending with error

4

151

March 17, 2026

Fq2bam stalls in single-end recovery mode

fq2bam

3

182

March 9, 2026

Healthcare & Life Sciences Parabricks