“Unused” means this UART is not used by the default software configuration; it does not mean the hardware connection is unavailable. The actual Device Tree status depends on your
JetPack/L4T release. NVIDIA previously confirmed that the M.2 Key E UART is not used by default. Related reply (https://forums.developer.nvidia.com/t/orin-nano-r36-4-uart0-
issue/333255/5)
The UART signals are routed to the M.2 Key E slot to support modules that require UART communication, such as Bluetooth modules using a UART HCI interface. Whether those signals
are used depends on the installed module; the connection does not imply that the supplied Wi-Fi/Bluetooth card uses UART. Related Bluetooth discussion (https:// UART0 flow control - #3 by KevinFFF)