It seems I broke my OS filesystem beyond repair. The box boots from SSD and works fine, except my opencv-cuda-python problem. As I am unable to fix this after I made some major mistakes while deleting opencv-references - I would like to start from factory settings again.
The support of my box told me
In easy way, if you have still use your Jetson with your external drive (SSD or SD card), you can delete it and re-transfer the file system from eMMC drive.
That seems the perfect idea, despite the fact, that they did not send me a guide how to do this.
Until now, I only found recipies for flashing using a second linux-pc (host?) and some hints about the APP-partition. Do I really need to flash my box or is it possible to delete the SSD and copy/rsync the files+links from the EMMC? (to me flashing sounds like modifying eMMC)