I created this bug report and have been the major contributor but lack the ability to understand it.
https://bugs.winehq.org/show_bug.cgi?id=44395
What is known:
Bug affects wine-preloader (32-bit code) in all Wine versions and recent Nvidia Proprietary drivers on Ubuntu 17.10. Nouveau is unaffected. Preloader apparently sets up the virtual environment like memory ranges, etc.
Can’t help to troubleshoot further but thought I’d share.