Hi. The shader cache may have different locations when running from Python instead of the Launcher. The path should be in the log file.
Usually, clearing the shader cache and re-running should solve most issues. The shader caching issue could also be caused by other configs or driver version too.
By default, Isaac Sim on Windows uses DirectX to render but enabling the “–vulkan” flag will force it to use the Vulkan API instead (Note: this Vulkan runtime library is included in the NVIDIA GPU drivers). Vulkan is used by default on Linux.
There are some differences between Vulkan and DirectX rendering paths but we have not seen any major issues. DirectX is preferred natively on Windows.