Hello,
I have used Parabricks to align WGS samples in my research and found it to be very fast and efficient. I am interested in applying it more broadly. I was wondering whether Parabricks has been extensively tested for whole-genome sequencing, or if it is primarily optimized for WES and targeted panels with respect to alignment performance and WGS metrics.
If yes, then can you please share the default for alignment and base quality cutoffs? is there a document or reference for this?
Thanks
Pushpa