Can omniverse run smoothly with two RTX2080ti?

And if can, is there something need to be watched out?

Yes, you’ll be fine with 2x 2080ti memory is the only issue you’ll need to look out for the 11gb is your only issue. Not performance. You oddly might be able to run smoother in Pathtracing at some point. The RTX rendering is awesome but when the scenes get huge, switch so you can use both better.