>>Grid vApps is not an option as the profile is limited to resolution of 1280*1024
is misleading , because it’s only true for console access (to prevent misuse of A-profiles to be used with Server Hosted VDI)
Each and every logon to RDS/XenApp through the sessions stack using HDX/RDP will be able to use multi-monitor setups.
You can run your VMs with A-profiles on top of ESXi.
There is only the one or the other … Quadro vDWS (Q-Profiles) or vApps license (A-Profiles)
>>From my understanding we could leverage Quadro vDWS in combination with Grid vApp license
For just hosting published Apps / published Desktops on top of a multi-user OS choose the vApps license and you are fine.