You are supposed to have read both the PCI Express Base Specification Revision 4.0 and the PCI Express Card Electromechanical Specification Revision 4.0. The latter says in section 4.7.5 “Lane-to-Lane Skew”:
Skew System Board: Value 1.25 ns: Estimates about a 7-inch trace length delta on FR4 boards.
7 inch delta is hard to reach.
For add-in cards the allowable skew is 0.35ns or 2 inch.