Windows defender was fully disabled during the installation and running service check.
Tested windows machine is VM on vmware ESXi 7 host with internet connection
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I tested same version of launcher on the baremetal windows 10 enterprise host, then the local nucleus server works fine. (without any port configuration on windows defender)
I can’t find any difference between them except the physical machine and VM.
Is this a self-hosted VM or are you using it on a cloud provider? This sounds like it may be a VM setting somewhere. We test Nucleus Workstation on bare metal for the most part, we do not test against VMs